Studies on Treponema Pallidum Immobilization Test

Studies on Treponema Pallidum and Syphilis

Although antibodies can be produced by the immunization of animals with cultivated Treponema pallidum, and although these antibodies exert specific agglutinative and treponemicidal action upon the culture organisms, they possess, at least in the concentration so far obtained by us in rabbits and sheep, practically no action for virulent treponemata obtained directly from lesions. There seems to...

Studies on Immunity in Experimental Syphilis. Ii. Treponema Pallidum Immobilization (tpi) Antibody and the Immune Response.

Studies on Treponema Pallidum and Syphilis. Ii. Spiroch~ticidal Antibodies against Treponema Pallidum. by Hans

In a previous communication we have reported on the agglufinins which are formed in rabbits following systematic inoculation with concentrated culture material of Treponema pallidum. Incidentally it may be stated that a sheep has also been successfully used. The antigen used for the immunization of these animals was similar to that employed in the first agglutination experiments, except that we...

Appraisal of the Treponema pallidum haemagglutination test.

Several attempts have been made to use haemagglutination reactions for the diagnosis of syphilis between 1932 and 1958. The first reliable method was developed by Rathlev (1965). Further results of investigations with this method have been reported by authors from Japan and from the Venereal Disease Research Laboratory in Atlanta, U.S.A. Rathlev prepared the reagents for the test in the Statens...

Streptomycin, sodium azide, and merthiolate as bacteriostatic agents for use with the Treponema pallidum immobilization test.

The problems of bacterial contamination associated with the shipment or preservation of serum specimens to be tested with the conventional serologic tests for syphilis are increased when such specimens are to be tested with the Treponema pallidum Immobilization (TPI) test. Bacterial contamination interferes with the ease and accuracy of reading the test and the metabolic or somatic products of ...